LYSERGIC ACID DIETHYLAMIDE-LSD

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LSD (lysergic acid diethylamide) is a synthetic chemical, made from a substance found in ergot, which is a fungus that infects rye (grain).1

When small doses are taken, it can produce mild changes in perception, mood and thought. Larger doses may produce visual hallucinations and distortions of space and time.

How is LSD used?

LSD is usually swallowed or dissolved under the tongue, but it can also be sniffed, injected or smoked.

The effects of LSD usually begin in approximately 30 minutes and will last around 8-12 hours.

LSD showed dose-proportional pharmacokinetics and first-order elimination and dose-dependently induced subjective responses starting at the 25 µg dose. A ceiling effect was observed for good drug effects at 100 µg. The 200 µg dose of LSD induced greater ego dissolution than the 100 µg dose and induced significant anxiety. The average duration of subjective effects increased from 6.7 to 11 h with increasing doses of 25–200 µg. LSD moderately increased blood pressure and heart rate. Ketanserin effectively prevented the response to 200 µg LSD. The LSD dose–response curve showed a ceiling effect for subjective good effects, and ego dissolution and anxiety increased further at a dose above 100 µg.